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Topical

Our extensive experience in skin science has led to the development of innovative ingredients that enhance the efficacy and patient perception of topical pharmaceuticals. Our topical excipients include drug delivery systems, skin penetration enhancers, solubilisers, emulsifiers and emollients.
Mother carefully applying medical ointment

Key issues affecting topical formulation are active pharmaceutical ingredient (API) instability, poor API solubilisation and skin irritation that minimises patient compliance.

The use of Super Refined™ excipients addresses these formulation concerns and maximises the value of your topical drug product. Our high purity range optimises troubled formulations by:

  • Improving stability of both drug and formulation.
  • Reducing oxidation potential.
  • Decreasing cellular irritation to improve patient compliance.
  • Maximising drug targeting on the skin surface.

To demonstrate enhanced API stability, we monitored the percentage of the API lidocaine that could be recovered over time when incorporated into Super Refined Crodamol™ OO (oleyl oleate) versus standard compendial oleyl oleate. It can be seen that lidocaine maintains its integrity and stability far better in Super Refined Crodamol OO, with significantly less API being recovered from standard compendial grade oleyl oleate.

To demonstrate oxidative stability, the peroxide value of Super Refined Crodamol OO was compared to standard compendial grade oleyl oleate over a 40 day study in accelerated ageing temperatures. It was noted that the Super Refined excipient maintained a low peroxide value while the standard compendial grade exhibited an approximate 70-fold increase in peroxide value, indicating that it has undergone significant primary oxidation.

API Stability Oxidative Stability

The efficacy of our dermatological ingredients is demonstrated by clinical studies across a range of therapies including skin hydration and barrier repair applications, emollient therapy and wound healing.

Formulating for...

Croda Health Care

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Emulsifier selector

Croda's emulsifier selector is a tool that can be used to help a formulator find the right ingredient for their needs. Whether it's a viscosity requirement, chemical characteristic, or a specific emulsion property, the emulsifier selector has the ability to filter and quickly identify the right ingredient for the right job.

medical glassware

Formulation finder

Browse our range of fully developed formulations for inspiration and guidance.

eczema on hand

Eczema

Eczema is a group of inflammatory skin disorders characterised by itchiness, dryness, scaling, sensitivity, cracking, and inflammation. Our dermatological solutions are designed to address these symptoms in a range of convenient formulations.

Star Ingredient: Medilan™ (Wool Fat PhEur; Modified Lanolin NF), approved by the British Skin Foundation

  • Replenishes the skin’s essential lipids.
  • Repairs the natural skin barrier to reduce transepidermal water loss.
  • Excellent skin hydration properties.
  • Provides long lasting emollience.
psoriasis,

Psoriasis

Psoriasis typically presents as raised red, flaky, crusty patches of skin covered with silvery scales that can be itchy and sore. Topical psoriasis formulations are intended for long term patient use and are tailored to the different areas of the body on which psoriasis can occur, eg shampoos for scalp psoriasis and emollient sticks for convenient spot application during the day. Star Ingredient: Crodamol ISIS™ (Isostearyl Isostearate)

  • Substantive, non-occlusive emollient.
  • Works with the lipids in the skin to achieve optimum hydration and moisturisation, outperforming artificial occlusion with petrolatum.
Close up of man with problematic skin and scars from acne

Acne

Formulating acne products requires light, non-occlusive ingredients to soothe inflamed skin, optimise the performance of anti-acne actives and encourage repeat use of the product.
Star Ingredient: Super Refined™ Arlasolve™ DMI (Dimethyl Isosorbide)

  • High purity, clear liquid epidermal penetration enhancer.
  • Excellent solubiliser.
  • Improves formulation and API stability.
  • Enhances spreading properties.
close-up portrait of a baby

Baby Skin

Baby skin has a delicate and fragile structure which easily becomes dry or irritated due to urine contact, laundry detergent residues and central heating and air conditioning. Formulating for baby skin requires mild, effective moisturising ingredients and a dosage form that is quick and easy to apply or use in the bath.
Star Ingredient: Arlamol™ PS11E (Polyoxypropylene Stearyl Ether PhEur)

  • Excellent polar solvent for a wide range of actives.
  • Non-occlusive emollient offering a velvety skin feel.
  • Enables compatibility of polar and non-polar oils, making it possible to couple two actives into one product.
  • Produces liquid crystal oleosomes when used with Brij S2, Brij S721 and Crodacol CS90. Oleosome systems enable longer lasting skin hydration, pH flexibility, and increased salt tolerance and stability.
medilan family

Why work with us

  • In-house technical experts to provide formulation support and troubleshooting during product development
  • Access model formulation solutions for common conditions such as eczema, acne and psoriasis
  • Our regulatory specialists take active roles within key industry regulatory bodies and have extensive experience in the submission and progression of new monographs. We are practised in supporting the use of novel and innovative excipients in customer formulations.
Get in touch

Topical recommended products

Discover our product offerings for topical applications

Super Refined™ PEG 400

Super Refined™ PEG 400

The Super Refined PEG range is a series of Super Refined polyethylene glycols offering pharmaceutical formulators highly purified hydrophilic excipients that can enhance active and formulation.....

Super Refined™ DMI

Super Refined™ DMI

High purity liquid for use with poorly soluble hydrophilic and hydrophobic actives Enhances the formulation and API stability in transdermal delivery systems Recommended topical usage levels of.....

Super Refined™ Beeswax

Super Refined™ Beeswax

Highly purified beeswax used in sustained release oral dosage forms and to increase viscosity of creams and ointments Modifies melting point of suppository bases Recommended topical usage levels of.....

Super Refined™ IPM

Super Refined™ IPM

Highly purified version of Crodamol IPM. Solvent used in topical formulations. Rapid absorption into the skin. Recommended topical usage levels of 0.5-5%.

Super Refined™ Brij™ O2

Super Refined™ Brij™ O2

Super Refined Brij O2 is a high purity naturally derived alcohol ethoxylate It can be utilised as a solubiliser or in emulsifier systems where a low HLB value is required The material has been.....

Cithrol™ DPHS pharma

Cithrol™ DPHS pharma

Solvent-free versatile polymeric emulsifier offering a solution to a wide variety of W/O applications Able to produce exceptionally stable very low viscosity W/O emulsions with a unique light.....

Doctor giving a senior woman a vaccination.

Injectable

The formulation of parenteral and injectable dosage forms present unique challenges in comparison to other administration routes.

vitamins and supplements

Oral

The development of oral drugs presents several challenges, including low solubility, instability of the formulation and ineffective delivery of the IFA. The selection of the correct oral excipient during the initial stage of development is a critical step in achieving the success of the formulation.

man using eye drop

Auricular, ophthalmic and nasal

Developing drugs to be delivered through the ophthalmic, auricular and nasal routes requires focus on essential factors, such as drug stability and endotoxin levels, which can impact the success of the formulation.

Do you want more information on products suitable for topical use?