Health Care -

Your samples

  • No items in the basket
  • Add more products View basket View products to order samples

Remove from basket

Are you sure you want to remove from the sample cart?

Your Language

English Português Español
Health Care
Health Care
  • Products and Applications
    • Product Finder
    • Dietary Supplements  
    • Eye, Ear & Nose  
    • Vaccine Adjuvants  
    • Omega 3 API  
    • Oral  
    • Parenteral  
    • Rectal and Vaginal  
    • Topical  
    • Veterinary Health  
      • Formulation Finder

        Formulation Finder

        Browse our range of fully developed formulations for inspiration and guidance.
        View
  • Technical Library
    • Formulation Finder
    • Brochures  
    • Datasheets and MSDS  
    • FDA IID Sheets  
    • Vaccine Adjuvants – Certificates of GMP Compliance  
    • Excipient Information Package  
    • Presentations  
    • Product Overview Sheets  
    • Videos  
    • Webinars  
      • Product Finder

        Product Finder

        Find a product to suit your needs from our high purity excipients portfolio.
        Product Finder
  • Discovery Zone
    • Product Effects
      • SEDDS and SMEDDS  
      • Increased Vaccine Efficacy  
      • Solubilisers and Emulsifiers  
      • Solvents  
      • Penetration Enhancers  
      • Controlled Release  
      • Skin Barrier Repair with Lanolin  
      • Film Forming Polymers  
    • Chemical Industry Helping to Fight COVID-19  
    • Our Technologies
      • Super Refined Excipients  
      • API grade Omega 3  
      • Vaccine Adjuvant Technology  
      • New Drug Delivery Technology – ProSilic®  
    • Emulsifier Selector  
    • Pharmaceutical Solubility Guide  
    • Veterinary Solubility Guide  
    • Leaders in Regulatory Excellence  
    • How We Can Help  
    • Events Calendar
      • Smarter Innovation Through Quality  
      • Product Effects

        Product Effects

        View our product offerings.
        View
  • News
    • Business News  
    • Events  
    • Innovation  
    • Sustainability  
    • Trends  
      • Events Calendar

        Events Calendar

        We will be present at key industry events taking place over the year around the globe.
        Events
  • Contact  
  1. Home
  2. Discovery Zone
  3. Pharmaceutical Solubility Guide

Pharmaceutical Solubility Guide

As API solubility continues to present challenges for the pharmaceutical formulator, Croda has determined the solubility of a range of actives in a number of Croda’s high purity excipients. This baseline of information can provide you, the scientist, with a clearer starting point for your development work.

Within this chart, the solubility of 14 drug actives was determined using a range of Croda excipients for the purpose of demonstrating their capabilities to solubilise APIs.

Total solubility of the selected drug actives were determined in the listed excipients and the appropriate solubility descriptors were applied using FDA recommended guidelines.

Please select actives below:

% Drug Recovery Key:

Very Soluble (V/S) - 50.00-100%

Freely Soluble (F/S) - 10.00-49.99%

Soluble (S) - 3.30-9.99%

Sparingly Soluble (S/S) - 1.00-3.29%

Slightly Soluble (S/S) - 0.10-0.99%

Very Slightly Soluble (V/S/S) - 0.01-0.09%

Practically Insoluble (P/I) - <0.01%

Product Name
  • Polar Excipients
  • Crodasol™ HS HP
  • Glycerox™ 767HC
  • Super Refined™ Arlasolve™ DMI
  • Super Refined™ Oleic Acid NF
  • Super Refined™ PEG 300
  • Super Refined™ PEG 400
  • Super Refined™ Polysorbate 20
  • Super Refined™ Propylene Glycol
  • Tween™ 80 HP
  • Non-polar Excipients
  • Crodamol™ DA
  • Crodamol™ GTCC
  • Span™ 20
  • Super Refined™ Corn NF EP
  • Super Refined™ Cottonseed NF
  • Super Refined™ Crodamol™ HL
  • Super Refined™ Crodamol™ IPM
  • Super Refined™ Crodamol IPP
  • Super Refined™ Crodamol™ OO
  • Super Refined™ Novol NF
  • Super Refined™ Olive
  • Super Refined™ Sesame
  • Super Refined™ Soybean
  • Reference
  • Water*
Chemical Description
  • Polar Excipients
  • PEG 660 12-Hydroxystearate
  • PEG 6 Caprylic/Capric Glycerides
  • Dimethyl Isosorbide
  • Purified Oleic Acid
  • Polyethylene Glycol 300
  • Polyethylene Glycol 400
  • Polysorbate 20
  • Propylene Glycol
  • Polysorbate 80
  • Non-polar Excipients
  • Diisopropyl Adipate
  • Triglycerides, Medium-Chain
  • Sorbitan Laurate
  • Maize Oil
  • Cottonseed Oil
  • Hexyl Laurate
  • Isopropyl Myristate
  • Isopropyl Palmitate
  • Oleyl Oleate
  • Oleyl Alcohol
  • Olive Oil
  • Sesame Oil
  • Soybean Oil
  • Reference
  • --
HLB
  • Polar Excipients
  • 15.0
  • 13.2
  • --
  • 1.0
  • --
  • --
  • 16.7
  • --
  • 15.0
  • Non-polar Excipients
  • --
  • --
  • 8.6
  • --
  • --
  • --
  • --
  • --
  • --
  • 14.5
  • --
  • --
  • --
  • Reference
  • --
MW=
LogP=
MW=
LogP=
MW=
LogP=
  • Polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Soluble
  • Freely Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Soluble
  • Soluble
  • Very Slightly Soluble
  • Soluble
  • Soluble
  • Soluble
  • Soluble
  • Soluble
  • Non-polar Excipients
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Sparingly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Soluble
  • Soluble
  • Freely Soluble
  • Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Soluble
  • Slightly Soluble
  • Soluble
  • Non-polar Excipients
  • Freely Soluble
  • Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Soluble
  • Soluble
  • Soluble
  • Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Soluble
  • Soluble
  • Reference
  • -
  • Polar Excipients
  • Freely Soluble
  • Freely Soluble
  • Freely Soluble
  • Soluble
  • Freely Soluble
  • Freely Soluble
  • Freely Soluble
  • Soluble
  • Freely Soluble
  • Non-polar Excipients
  • Soluble
  • Soluble
  • Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Soluble
  • Soluble
  • Soluble
  • Sparingly Soluble
  • Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Reference
  • -
  • Polar Excipients
  • Slightly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Non-polar Excipients
  • -
  • Very Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Practically Insoluble
  • -
  • -
  • -
  • -
  • Very Slightly Soluble
  • Practically Insoluble
  • Practically Insoluble
  • Very Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Practically Insoluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Non-polar Excipients
  • Very Slightly Soluble
  • Practically Insoluble
  • Very Slightly Soluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Non-polar Excipients
  • Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Freely Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Non-polar Excipients
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Slightly Soluble
  • -
  • Sparingly Soluble
  • -
  • -
  • -
  • -
  • -
  • Slightly Soluble
  • Non-polar Excipients
  • -
  • -
  • -
  • -
  • -
  • -
  • Very Slightly Soluble
  • -
  • -
  • -
  • -
  • -
  • -
  • Reference
  • -
  • Polar Excipients
  • Freely Soluble
  • -
  • Freely Soluble
  • -
  • -
  • -
  • -
  • -
  • Freely Soluble
  • Non-polar Excipients
  • -
  • -
  • -
  • -
  • -
  • -
  • Soluble
  • -
  • -
  • -
  • -
  • -
  • -
  • Reference
  • -
  • Polar Excipients
  • Slightly Soluble
  • Sparingly Soluble
  • Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • Slightly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Soluble
  • Very Slightly Soluble
  • Soluble
  • Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Freely Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Non-polar Excipients
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Practically Insoluble
  • Practically Insoluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Reference
  • -

The key descriptions above are based on the % recovery of the APIs.
* The water solubility of the specified actives is classified as it appears in the monograph for each active

Product Finder Search our product database
MSDS Search for a material safety datasheet
Contact Us Contact your local office

Health Care

We at Croda contribute to a healthier world by offering ingredients and formulation expertise which help our pharmaceutical customers get the best performance from their active ingredients.

Follow us on social media
  • Health Care on LinkedIn

Corporate

  • Products and markets
  • Where we operate
  • Current vacancies
  • Annual Report
  • Sustainability Reports
  • GRI Report
Visit our corporate site
© 2021 Croda International Plc
© 2021 Croda International Plc | Terms and Conditions | Privacy Policy | Accessibility statement

About cookies on this site
By continuing to use this website, you agree to the use of cookies. You can find out more details in our Privacy policy.