Pharmaceutical Solubility Guide

As API solubility continues to present challenges for the pharmaceutical formulator, Croda has determined the solubility of a range of actives in a number of Croda’s high purity excipients. This baseline of information can provide you, the scientist, with a clearer starting point for your development work.

Within this chart, the solubility of 14 drug actives was determined using a range of Croda excipients for the purpose of demonstrating their capabilities to solubilise APIs.

Total solubility of the selected drug actives were determined in the listed excipients and the appropriate solubility descriptors were applied using FDA recommended guidelines.

Please select actives below:

% Drug Recovery Key:

Very Soluble (V/S) - 50.00-100%

Freely Soluble (F/S) - 10.00-49.99%

Soluble (S) - 3.30-9.99%

Sparingly Soluble (S/S) - 1.00-3.29%

Slightly Soluble (S/S) - 0.10-0.99%

Very Slightly Soluble (V/S/S) - 0.01-0.09%

Practically Insoluble (P/I) - <0.01%

Product Name

Chemical Description

Polar Excipients
PEG 660 12-Hydroxystearate
PEG 6 Caprylic/Capric Glycerides
Dimethyl Isosorbide
Purified Oleic Acid
Polyethylene Glycol 300
Polyethylene Glycol 400
Polysorbate 20
Propylene Glycol
Polysorbate 80
Non-polar Excipients
Diisopropyl Adipate
Triglycerides, Medium-Chain
Sorbitan Laurate
Maize Oil
Cottonseed Oil
Hexyl Laurate
Isopropyl Myristate
Isopropyl Palmitate
Oleyl Oleate
Oleyl Alcohol
Olive Oil
Sesame Oil
Soybean Oil
Reference
--

HLB

Polar Excipients
15.0
13.2
--
1.0
--
--
16.7
--
15.0
Non-polar Excipients
--
--
8.6
--
--
--
--
--
--
14.5
--
--
--
Reference
--

MW=

LogP=

MW=

LogP=

MW=

LogP=

Polar Excipients
Sparingly Soluble
Sparingly Soluble
Soluble
Freely Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Sparingly Soluble
Non-polar Excipients
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Reference
-

Polar Excipients
Sparingly Soluble
Soluble
Soluble
Very Slightly Soluble
Soluble
Soluble
Soluble
Soluble
Soluble
Non-polar Excipients
Slightly Soluble
Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Sparingly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Reference
-

Polar Excipients
Soluble
Soluble
Freely Soluble
Soluble
Sparingly Soluble
Sparingly Soluble
Soluble
Slightly Soluble
Soluble
Non-polar Excipients
Freely Soluble
Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Soluble
Soluble
Soluble
Soluble
Sparingly Soluble
Sparingly Soluble
Soluble
Soluble
Reference
-

Polar Excipients
Freely Soluble
Freely Soluble
Freely Soluble
Soluble
Freely Soluble
Freely Soluble
Freely Soluble
Soluble
Freely Soluble
Non-polar Excipients
Soluble
Soluble
Soluble
Sparingly Soluble
Sparingly Soluble
Soluble
Soluble
Soluble
Sparingly Soluble
Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Reference
-

Polar Excipients
Slightly Soluble
Slightly Soluble
Sparingly Soluble
Very Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Non-polar Excipients
-
Very Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Practically Insoluble
-
-
-
-
Very Slightly Soluble
Practically Insoluble
Practically Insoluble
Very Slightly Soluble
Reference
-

Polar Excipients
Slightly Soluble
Slightly Soluble
Slightly Soluble
Practically Insoluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Non-polar Excipients
Very Slightly Soluble
Practically Insoluble
Very Slightly Soluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
Reference
-

Polar Excipients
Sparingly Soluble
Slightly Soluble
Sparingly Soluble
Very Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Non-polar Excipients
Soluble
Very Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Reference
-

Polar Excipients
Sparingly Soluble
Slightly Soluble
Sparingly Soluble
Freely Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Non-polar Excipients
Slightly Soluble
Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Reference
-

Polar Excipients
Slightly Soluble
-
Sparingly Soluble
-
-
-
-
-
Slightly Soluble
Non-polar Excipients
-
-
-
-
-
-
Very Slightly Soluble
-
-
-
-
-
-
Reference
-

Polar Excipients
Freely Soluble
-
Freely Soluble
-
-
-
-
-
Freely Soluble
Non-polar Excipients
-
-
-
-
-
-
Soluble
-
-
-
-
-
-
Reference
-

Polar Excipients
Slightly Soluble
Sparingly Soluble
Soluble
Slightly Soluble
Sparingly Soluble
Sparingly Soluble
Slightly Soluble
Slightly Soluble
Sparingly Soluble
Non-polar Excipients
Slightly Soluble
Slightly Soluble
Sparingly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Reference
-

Polar Excipients
Sparingly Soluble
Sparingly Soluble
Soluble
Very Slightly Soluble
Soluble
Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Non-polar Excipients
Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Reference
-

Polar Excipients
Sparingly Soluble
Sparingly Soluble
Freely Soluble
Slightly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Non-polar Excipients
Soluble
Slightly Soluble
Sparingly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Reference
-

Polar Excipients
Slightly Soluble
Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Non-polar Excipients
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Practically Insoluble
Practically Insoluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Reference
-

The key descriptions above are based on the % recovery of the APIs.
* The water solubility of the specified actives is classified as it appears in the monograph for each active