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  3. Veterinary Solubility Guide

Veterinary Solubility Guide

As API solubility continues to present challenges for the veterinary formulator, Croda has determined the solubility of a range of actives in a number of Croda’s high purity excipients. This baseline of information can provide you, the scientist, with a clearer starting point for your development work.

Within this chart, the solubility of 8 drug actives was determined using a range of Croda excipients for the purpose of demonstrating their capabilities to solubilise APIs.

Total solubility of the selected drug actives were determined in the listed excipients and the appropriate solubility descriptors were applied using FDA recommended guIdelines.

Please select actives below:

% Drug Recovery Key:

Very Soluble (V/S) - 50.00-100%

Freely Soluble (F/S) - 10.00-49.99%

Soluble (S) - 3.30-9.99%

Sparingly Soluble (S/S) - 1.00-3.29%

Slightly Soluble (S/S) - 0.10-0.99%

Very Slightly Soluble (V/S/S) - 0.01-0.09%

Practically Insoluble (P/I) - <0.01%

Product Name
  • Polar Excipients
  • Crodasol™ HS HP
  • NatraGem™ S140
  • NatraGem™ S150
  • Super Refined™ Arlasolve™ DMI
  • Super Refined™ Oleic Acid NF
  • Super Refined™ PEG 400
  • Super Refined™ Propylene Glycol
  • Tween™ 20 HP
  • Tween™ 80 HP
  • Non-polar Excipients
  • Cromollient™ DP3A
  • Cromollient™ SCE
  • Super Refined™ Castor Oil
  • Super Refined™ SCO
  • Super Refined™ Novol NF
  • Reference
  • Water*
Chemical Description
  • Polar Excipients
  • PEG 660 12-Hydroxystearate
  • Polyglyceryl-4 Laurate/Sebacate (and) Polyglyceryl-6 Caprylate/Caprate (and) Aqua
  • Polyglyceryl-4 Laurate/Sebacate (and) Polyglyceryl-4 Caprylate/Caprate (and) Aqua
  • Dimethyl Isosorbide
  • Purified Oleic Acid
  • Polyethylene Glycol 400
  • Propylene Glycol
  • Polysorbate 20
  • Polysorbate 80
  • Non-polar Excipients
  • Di-PPG-3 Myristyl Ether Adipate
  • Di-PPG 2 Myreth-10 Adipate
  • Castor Oil
  • Stearyl Octanoate (and) Cetyl Octanoate
  • Oleyl Alcohol
  • Reference
  • --
HLB
  • Polar Excipients
  • 15.0
  • 14.0
  • 15.0
  • --
  • 1.0
  • --
  • --
  • 16.7
  • 15.0
  • Non-polar Excipients
  • 11.0
  • --
  • --
  • --
  • 14.5
  • Reference
  • --
MW=
LogP=
MW=
LogP=
MW=
LogP=
  • Polar Excipients
  • Practically Insoluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • -
  • Slightly Soluble
  • Slightly Soluble
  • Practically Insoluble
  • Practically Insoluble
  • Non-polar Excipients
  • Practically Insoluble
  • Practically Insoluble
  • Very Slightly Soluble
  • Practically Insoluble
  • -
  • Reference
  • -
  • Polar Excipients
  • -
  • -
  • -
  • -
  • -
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • -
  • -
  • Practically Insoluble
  • -
  • -
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Very Slightly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • Very Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Practically Insoluble
  • Very Slightly Soluble
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • -
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • -
  • Reference
  • -
  • Polar Excipients
  • Slightly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Practically Insoluble
  • -
  • Sparingly Soluble
  • Sparingly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Non-polar Excipients
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • Practically Insoluble
  • -
  • Reference
  • -
  • Polar Excipients
  • Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • -
  • Slightly Soluble
  • Very Slightly Soluble
  • Slightly Soluble
  • Slightly Soluble
  • Non-polar Excipients
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • Very Slightly Soluble
  • -
  • Reference
  • -
  • Polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Non-polar Excipients
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Sparingly Soluble
  • Reference
  • -

The key descriptions above are based on the % recovery of the APIs.
* The water solubility of the specified actives is classified as it appears in the monograph for each active

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