Veterinary Solubility Guide

As API solubility continues to present challenges for the veterinary formulator, Croda has determined the solubility of a range of actives in a number of Croda’s high purity excipients. This baseline of information can provide you, the scientist, with a clearer starting point for your development work.

Within this chart, the solubility of 8 drug actives was determined using a range of Croda excipients for the purpose of demonstrating their capabilities to solubilise APIs.

Total solubility of the selected drug actives were determined in the listed excipients and the appropriate solubility descriptors were applied using FDA recommended guIdelines.

Please select actives below:

% Drug Recovery Key:

Very Soluble (V/S) - 50.00-100%

Freely Soluble (F/S) - 10.00-49.99%

Soluble (S) - 3.30-9.99%

Sparingly Soluble (S/S) - 1.00-3.29%

Slightly Soluble (S/S) - 0.10-0.99%

Very Slightly Soluble (V/S/S) - 0.01-0.09%

Practically Insoluble (P/I) - <0.01%

Product name

Chemical description

Polar excipients
PEG 660 12-Hydroxystearate
Polyglyceryl-4 Laurate/Sebacate (and) Polyglyceryl-6 Caprylate/Caprate (and) Aqua
Polyglyceryl-4 Laurate/Sebacate (and) Polyglyceryl-4 Caprylate/Caprate (and) Aqua
Dimethyl Isosorbide
Purified Oleic Acid
Polyethylene Glycol 400
Propylene Glycol
Polysorbate 20
Polysorbate 80
Non-polar excipients
Di-PPG-3 Myristyl Ether Adipate
Di-PPG 2 Myreth-10 Adipate
Castor Oil
Stearyl Octanoate (and) Cetyl Octanoate
Oleyl Alcohol
Reference
--

HLB

Polar excipients
15.0
14.0
15.0
--
1.0
--
--
16.7
15.0
Non-polar excipients
11.0
--
--
--
14.5
Reference
--

MW=

LogP=

MW=

LogP=

MW=

LogP=

Polar excipients
Practically Insoluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
-
Slightly Soluble
Slightly Soluble
Practically Insoluble
Practically Insoluble
Non-polar excipients
Practically Insoluble
Practically Insoluble
Very Slightly Soluble
Practically Insoluble
-
Reference
-

Polar excipients
-
-
-
-
-
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Non-polar excipients
-
-
Practically Insoluble
-
-
Reference
-

Polar excipients
Sparingly Soluble
Slightly Soluble
Slightly Soluble
Sparingly Soluble
Slightly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Non-polar excipients
Sparingly Soluble
Sparingly Soluble
Slightly Soluble
Slightly Soluble
Slightly Soluble
Reference
-

Polar excipients
Sparingly Soluble
Slightly Soluble
Slightly Soluble
Sparingly Soluble
Very Slightly Soluble
Sparingly Soluble
Slightly Soluble
Sparingly Soluble
Sparingly Soluble
Non-polar excipients
Very Slightly Soluble
Slightly Soluble
Slightly Soluble
Practically Insoluble
Very Slightly Soluble
Reference
-

Polar excipients
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
-
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Non-polar excipients
Sparingly Soluble
Sparingly Soluble
Slightly Soluble
Slightly Soluble
-
Reference
-

Polar excipients
Slightly Soluble
Sparingly Soluble
Sparingly Soluble
Practically Insoluble
-
Sparingly Soluble
Sparingly Soluble
Slightly Soluble
Slightly Soluble
Non-polar excipients
Practically Insoluble
Practically Insoluble
Practically Insoluble
Practically Insoluble
-
Reference
-

Polar excipients
Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Slightly Soluble
-
Slightly Soluble
Very Slightly Soluble
Slightly Soluble
Slightly Soluble
Non-polar excipients
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
Very Slightly Soluble
-
Reference
-

Polar excipients
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Non-polar excipients
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Sparingly Soluble
Reference
-

The key descriptions above are based on the % recovery of the APIs.
* The water solubility of the specified actives is classified as it appears in the monograph for each active