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Pharmaceutical solvents

Achieving API solubility is one of the big challenges faced by formulators, with many APIs having low solubility. Our range of Super Refined pharmaceutical solvents can address this challenge, providing a range of polar and non-polar solvents that not only provide solubility, but also excellent stability for APIs. 

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Our Super Refined™ pharmaceutical solvents are compliant with the stringent requirements of the Ph. Eur., USP/NF and JP/JPE monographs. Super Refined solvents can be used for numerous dosage forms, and have excellent organoleptic properties as they are essentially colourless and low in both odour and taste.

Super Refining removes such polar impurities (including primary and secondary oxidation products) from natural oils without altering fundamental triglyceride profiles which helps to: 

  • Reduce API interaction and degradation 
  • Generate batch to batch consistency in terms of minimal colour, odour and taste. 

Similar benefits are also found with Super Refined polyethylene glycols (PEG) in comparison to standard compendial polyethylene glycols, including: 

  • Improved API stability and finished formulation integrity 
  • Reduced potential for cellular irritation 
  • Improved taste profile when used in oral liquid dosage forms 
What additional benefits can solvents provide? 

Pharmaceutical solvents can solubilise APIs for a wide range of delivery routes such as parenteral, oral, topical, ophthalmic and otic delivery. Some solvents , however, also bring additional functionality to the formulation. 

Super Refined Benzyl Alcohol acts as a preservative and can reduce formulation viscosity.

Super Refined DMI acts as a penetration enhancer for topical delivery.

Super Refined PEG 400 can reduce crosslinking when used in gelatin capsules.

Super Refined Oils can serve numerous purposes, such as vehicles in vaccines, solubilisers in oral formulations, or viscosity modifiers in topical formulations.

What are the main concerns with oils when it comes to purity?

Naturally derived triglyceride oils possess colour, odour and have a distinctive taste that is characteristic of the specific oil. The intensity of these parameters depends on natural growing conditions and the extraction methods used for the oil, resulting in product variability. Polar impurities are present in triglycerides, usually consisting of monoglycerides, diglycerides, free fatty acids, plant sterols, colouring matter (chlorophyll, carotene), environmental chemicals and oxidation products (since natural triglyceride oils are usually oxidatively unstable). 

Super Refined™ PEGs

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Super Refined™ Oils

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Pharmaceutical solubility guide

As API solubility continues to present challenges for the pharmaceutical formulator, Croda has determined the solubility of a range of actives in a number of Croda’s high purity excipients.

View our recommended products

Super Refined™ DEGEE

Super Refined™ DEGEE

Super Refined DEGEE is a multi-compendial high purity glycol ether This clear colourless liquid demonstrates outstanding permeation enhancement and improved delivery and bioavailability for.....

Super Refined™ Cottonseed

Super Refined™ Cottonseed

Cottonseed-derived triglyceride that has been Super Refined™ to remove impurities.

Super Refined™ Castor Oil

Super Refined™ Castor Oil

Super Refined Castor Oil is a highly purified version of naturally derived castor oil which has a high degree of functionality making it an extremely useful excipient However this increased.....

Super Refined™ PEG 400

Super Refined™ PEG 400

The Super Refined PEG range is a series of Super Refined polyethylene glycols offering pharmaceutical formulators highly purified hydrophilic excipients that can enhance active and formulation.....

Super Refined™ PEG 600

Super Refined™ PEG 600

Super Refined PEGs are solvents for use with the most sensitive active ingredients across dosage forms including injectable and oral Super Refining removes polar impurities (including primary and.....

Super Refined™ PEG 300

Super Refined™ PEG 300

The Super Refined PEG range is a series of Super Refined polyethylene glycols offering pharmaceutical formulators highly purified hydrophilic excipients that can enhance active and formulation.....

Super Refined™ Benzyl Alcohol

Super Refined™ Benzyl Alcohol

Super Refined™ Benzyl Alcohol is a high purity aromatic alcohol suitable for use as a preservative solvent and viscosity reducing agent Boasting benefits such as very low benzaldehyde and peroxide.....

Super Refined™ DMI

Super Refined™ DMI

High purity liquid for use with poorly soluble hydrophilic and hydrophobic actives Enhances the formulation and API stability in transdermal delivery systems Recommended topical usage levels of.....

Super Refined™ Oleic Acid

Super Refined™ Oleic Acid

Highly purified oleic acid is used as a co-emulsifier in topical pharmaceutical formulations Ideal for nasal drug delivery and as a penetration enhancer in transdermal formulations In addition it.....

Super Refined™ Oleyl Alcohol

Super Refined™ Oleyl Alcohol

Highly purified lipid-based solubiliser and skin penetration enhancer Ideal for wetting and dispersing actives within topical creams and ointment applications It is an ideal excipient for use in.....

Scientist creating health care formulation at Croda

Super Refined™ Propylene Glycol

Super Refined Propylene Glycol is a highly purified propylene glycol that has a wide use in pharmaceutical formulations as a solvent stablilising agent water-miscible cosolvent plasticiser.....

Crodamol™ EO pharma

Crodamol™ EO pharma

Low viscosity solvent for lipophilic actives. Rapidly absorbed by body tissues. Dermal penetration enhancer. Required HLB value of 11. Recommended topical usage levels of 0.5-5%.

Super Refined™ IPM

Super Refined™ IPM

Highly purified version of Crodamol IPM. Solvent used in topical formulations. Rapid absorption into the skin. Recommended topical usage levels of 0.5-5%.

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