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Super Refined™ Excipients

Super Refined™ excipients

Croda offers a wide variety of chemistries catering to the various needs and challenges faced by drug development scientists and pharmaceutical formulators. From stabilising a drug in solution to improving its delivery profile to achieving the right sensory properties for a final product, we have everything you need to help you formulate seamlessly and drive your products to market. For the needs of very sensitive applications, we’ve developed our Super Refined range of excipients, to ensure that your formulations are stable, effective and consistent.

Super Refined™ Excipients
Why choose Super Refined ingredients?

Selection of the right excipient which is compatible with both your drug and your formulation can mean the difference between a blockbuster drug and a failed drug. Many excipients come with a variety of impurities and byproducts which can hinder product performance and cause formation of potentially dangerous and toxic degradants.

Super Refined excipients are stripped of a number of oxidative impurities, such as peroxides, aldehydes, and catalyst residues. The removal of these problematic species helps to reduce negative API & excipient interactions, maintaining both the stability of the drug and the final formulation.  In addition, the removal of these impurities can minimise cellular irritation, reduce taste impact, and potentially decrease allergenicity.

Additionally, many of our products meet the needs of multiple monographs such as the USP/NF, PhEur, JP/JPE, and ChP.

What do you offer in your Super Refined line of products?

We have a large variety of products, ranging from various polysorbates, polyethylene glycols (PEG), esters, vegetable oils, and more. Don’t see something that you need? Connect with us and we’ll be able to make it for you! We pride ourselves on working with our customers to get them the solutions they need for market success.

What can your Super Refined products be used for?

Whatever you need! Many of our products are listed on the FDA’s Inactive Ingredient Database (IID) for a number of dosage routes:

Maximise the Performance of Your APIs

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The Power of Excipient Purity in API Stability

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Doctor giving a senior woman a vaccination.

Injectable

The formulation of parenteral and injectable dosage forms present unique challenges in comparison to other administration routes.

vitamins and supplements

Oral

The development of oral drugs presents several challenges, including low solubility, instability of the formulation and ineffective delivery of the IFA. The selection of the correct oral excipient during the initial stage of development is a critical step in achieving the success of the formulation.

Women applying hand cream

Topical

Our extensive experience in skin science has led to the development of innovative ingredients that enhance the efficacy and patient perception of topical pharmaceuticals. Our topical excipients include drug delivery systems, skin penetration enhancers, solubilisers, emulsifiers and emollients.

man using eye drop

Auricular, ophthalmic and nasal

Developing drugs to be delivered through the ophthalmic, auricular and nasal routes requires focus on essential factors, such as drug stability and endotoxin levels, which can impact the success of the formulation.

View Our Super Refined™ range

Drugs can be inherently unstable, and readily react with impurities found in excipients. This can lead to formation of side products, thereby reducing drug efficacy. Using Super Refined™ ingredients not only ensures that your drug will remain stable in solution, but can also make analysis of the product significantly easier.

Super Refined™ Benzyl Alcohol

Super Refined™ Benzyl Alcohol

Super Refined™ Benzyl Alcohol is a high purity aromatic alcohol suitable for use as a preservative solvent and viscosity reducing agent Boasting benefits such as very low benzaldehyde and peroxide.....

Super Refined™  Polysorbate 80

Super Refined™ Polysorbate 80

Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral Super Refining removes impurities (including primary and.....

Super Refined™  Sesame Oil

Super Refined™ Sesame Oil

Sesame-derived triglyceride that has been Super Refined™ to remove impurities Purified to yield a water-white odourless neutral non-polar lipid with a low peroxide value Its major use is as a.....

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Smarter Innovation Through Quality Virtual Conference

Did you miss our Smarter Innovation Through Quality virtual conference? Follow the link to access all the sessions and video content on demand. Learn about a variety of subjects from quality matters to regulatory insights, and product innovations to formulation expertise.
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