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  4. Super Refined Crodamol IPM

Super Refined™ Crodamol™ IPM

Chemical Description

Isopropyl Myristate

Product Description

Highly purified grade of isopropyl myristate for use with sensitive active pharmaceutical ingredients or in applications where standard Crodamol IPM is not suitable. The proprietary Super Refining process removes impurities without altering the chemical composition of the excipient. This reduces the potential for adverse interactions between the excipient and the API, enhancing active stability and efficacy. Super Refined Crodamol IPM is a lipophilic enhancer that promotes skin penetration by means of bilayer disruption and disordering. It assists the percutaneous absorption of water-soluble and oil-soluble drugs by means of partial leaching of the epidermal lipids. The bilayer architecture of the stratum corneum lipids is disorganised by the introduction of phase separation and direct disruption of a proper lamellar arrangement. This results in the improvement of the skin’s reception for transdermal and transfollicular penetration.

Pharmacopoeia Compliance

  • FDA-IID Listed
  • JP
  • PhEur
  • USP/NF
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  • Details
  • Properties
  • (10) Literature
Chemical Group
  • Ester
Market Application
  • Human Pharmaceutical
  • Veterinary Health
Functions
  • Emollient
  • Self-emulsifying drug delivery
Administration Route
  • Auricular
  • Nasal
  • Ophthalmic
  • Topical
Typical Properties
Physical Form
  • Colourless liquid
Literature

High Purity Excipients

Looking to enhance the bioavailability, delivery and efficacy of your dosage form? Our high purity excipients optimise the stability of your API and the performance of your formulations.

Language: English | Type: Brochure | Size: 538.5kb

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Enhancing Penetration of Topical Actives

In the absence of penetration enhancing agents, few drugs are capable of penetrating the skin or mucous membranes in therapeutically effective concentrations. Croda's range of SUPER REFINED penetration enhancers maximize the efficacy of topical formulations by allowing for more targeted API delivery, ensuring optimal dosage where it matters most.

Language: English | Type: Brochure | Size: 90kb

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Crodamol Range

Language: Portuguese | Type: Data Sheet | Size: 389kb

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FDA Eye, Ears & Nose

Language: Portuguese | Type: Poster | Size: 901kb

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Topical Dosage Form Excipients

Language: Portuguese | Type: Data Sheet | Size: 519kb

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FDA Topical Chart

Language: Portuguese | Type: Poster | Size: 433kb

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FDA Vaginal/Rectal Chart

Language: Portuguese | Type: Poster | Size: 311kb

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Topical Dosage Form Excipients

Language: Spanish | Type: Data Sheet | Size: 138kb

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Crodamol Range

Language: Spanish | Type: Data Sheet | Size: 249kb

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Solubility Guide - Optimising Formulation Success

As API solubility continues to present challenges for the pharmaceutical formulator, in order to address this we have determined the solubility of a range of actives in a number of our high purity excipients. This baseline of information can provide you, the scientist, with a clearer starting point for your development work. Within this solubility guide, the solubility of 12 drug actives was determined using a range of our excipients for the purpose of demonstrating our capabilities to solubilise APIs.

Language: English | Type: Brochure | Size: 830.21kb

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