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  4. Super Refined Novol NF

Super Refined™ Novol NF

Chemical Description

Oleyl Alcohol

Product Description

Super Refined Novol NF is a highly purified lipid-based solubiliser and skin penetration enhancer that acts as a wetting agent and active dispersant in topical creams and ointment applications. Super Refined Novol is a lipophilic enhancer that promotes skin penetration by means of bilayer disruption and disordering. It assists the percutaneous absorption of water-soluble and oil-soluble drugs by means of partial leaching of the epidermal lipids. The bilayer architecture of the stratum corneum lipids is disorganised by the introduction of phase separation and direct disruption of a proper lamellar arrangement. This results in the improvement of the skin’s reception for transdermal and transfollicular penetration. The proprietary Super Refining process removes impurities without altering the chemical composition of the excipient. This reduces the potential for adverse interactions between the excipient and the API, enhancing active stability and efficacy. 

Pharmacopoeia Compliance

  • FDA-IID Listed
  • PhEur
  • USP/NF
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  • Details
  • Properties
  • (7) Literature
Chemical Group
  • Fatty alcohol
Market Application
  • Human Pharmaceutical
  • Veterinary Health
Functions
  • Emollient
  • Nonionic surfactant
Administration Route
  • Topical
Typical Properties
Physical Form
  • Clear, essentially colourless liquid
Literature

Enhancing Penetration of Topical Actives

In the absence of penetration enhancing agents, few drugs are capable of penetrating the skin or mucous membranes in therapeutically effective concentrations. Croda's range of SUPER REFINED penetration enhancers maximize the efficacy of topical formulations by allowing for more targeted API delivery, ensuring optimal dosage where it matters most.

Language: English | Type: Brochure | Size: 90kb

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High Purity Excipients

Looking to enhance the bioavailability, delivery and efficacy of your dosage form? Our high purity excipients optimise the stability of your API and the performance of your formulations.

Language: English | Type: Brochure | Size: 538.5kb

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Solubility Guide - Optimising Formulation Success

As API solubility continues to present challenges for the pharmaceutical formulator, in order to address this we have determined the solubility of a range of actives in a number of our high purity excipients. This baseline of information can provide you, the scientist, with a clearer starting point for your development work. Within this solubility guide, the solubility of 12 drug actives was determined using a range of our excipients for the purpose of demonstrating our capabilities to solubilise APIs.

Language: English | Type: Brochure | Size: 830.21kb

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Super Refined Novol NF

Super Refined Novol is Oleyl Alcohol and conforms to the National Formulary (NF) Monograph. Super Refined Novol is a mixture of high molecular weight saturated and unsaturated fatty alcohols where Oleyl Alcohol, the C18 mono-unsaturate is the predominant species. As a result of Super Refining, the product is completely colourless, odourless and tasteless. This product is plant derived and therefore free of any animal derivatives.

Language: English | Type: Data Sheet | Size: 58.52kb

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Topical Dosage Form Excipients

Language: Portuguese | Type: Data Sheet | Size: 519kb

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Topical Dosage Form Excipients

Language: Spanish | Type: Data Sheet | Size: 138kb

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FDA Topical Chart

Language: Portuguese | Type: Poster | Size: 433kb

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