Super Refined™ Novol NF

Chemical Description

Oleyl Alcohol

Product Description

Super Refined Novol NF is a highly purified lipid-based solubiliser and skin penetration enhancer that acts as a wetting agent and active dispersant in topical creams and ointment applications. Super Refined Novol is a lipophilic enhancer that promotes skin penetration by means of bilayer disruption and disordering. It assists the percutaneous absorption of water-soluble and oil-soluble drugs by means of partial leaching of the epidermal lipids. The bilayer architecture of the stratum corneum lipids is disorganised by the introduction of phase separation and direct disruption of a proper lamellar arrangement. This results in the improvement of the skin’s reception for transdermal and transfollicular penetration. The proprietary Super Refining process removes impurities without altering the chemical composition of the excipient. This reduces the potential for adverse interactions between the excipient and the API, enhancing active stability and efficacy.

Pharmacopoeia Compliance

FDA-IID Listed
PhEur
USP/NF

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Chemical Group

Fatty alcohol

Market Application

Human Pharmaceutical
Veterinary Health

Functions

Emollient
Nonionic surfactant

Administration Route

Topical

Typical Properties

Physical form

Clear, essentially colourless liquid

Literature

English Portuguese Spanish

Enhancing Penetration of Topical Actives

In the absence of penetration enhancing agents, few drugs are capable of penetrating the skin or mucous membranes in therapeutically effective concentrations. Croda's range of SUPER REFINED penetration enhancers maximize the efficacy of topical formulations by allowing for more targeted API delivery, ensuring optimal dosage where it matters most.

Language: English | Type: Brochure | Size: 90kb

High Purity Excipients

Looking to enhance the bioavailability, delivery and efficacy of your dosage form? Our high purity excipients optimise the stability of your API and the performance of your formulations.

Language: English | Type: Brochure | Size: 538.5kb

Solubility Guide - Optimising Formulation Success

As API solubility continues to present challenges for the pharmaceutical formulator, in order to address this we have determined the solubility of a range of actives in a number of our high purity excipients. This baseline of information can provide you, the scientist, with a clearer starting point for your development work. Within this solubility guide, the solubility of 12 drug actives was determined using a range of our excipients for the purpose of demonstrating our capabilities to solubilise APIs.

Language: English | Type: Brochure | Size: 830.21kb

Super Refined Novol NF

Super Refined Novol is Oleyl Alcohol and conforms to the National Formulary (NF) Monograph. Super Refined Novol is a mixture of high molecular weight saturated and unsaturated fatty alcohols where Oleyl Alcohol, the C18 mono-unsaturate is the predominant species. As a result of Super Refining, the product is completely colourless, odourless and tasteless. This product is plant derived and therefore free of any animal derivatives.

Language: English | Type: Data Sheet | Size: 58.52kb

Topical Dosage Form Excipients

Language: Portuguese | Type: Data Sheet | Size: 519kb

Topical Dosage Form Excipients

Language: Spanish | Type: Data Sheet | Size: 138kb

FDA Topical Chart

Language: Portuguese | Type: Poster | Size: 433kb

Super Refined™ Novol NF

Chemical Description

Product Description

Pharmacopoeia Compliance

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Chemical Group

Market Application

Functions

Administration Route

Typical Properties

Physical form

Literature

Enhancing Penetration of Topical Actives

High Purity Excipients

Solubility Guide - Optimising Formulation Success

Super Refined Novol NF

Topical Dosage Form Excipients

Topical Dosage Form Excipients

FDA Topical Chart