Quil-A is a highly purified and concentrated saponin adjuvant purified from bark extract of the Quillaja saponaria Molina tree which has been specifically developed for use as an adjuvant in vaccines. Quil-A saponin was originally purified and characterised by Dr. Pharm. Kristian Dalsgaard in 1974 and adapted for commercial scale production. It consists of a complex mixture of approximately 25 different saponin molecules which have the triterpenoid backbone in common. It is a very versatile adjuvant due to its ability to induce a balanced immune response to protect against both intracellular (Th1) and extracellular (Th2) pathogens.
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