Rectal and vaginal administration routes are used for local as well as systemic drug delivery and can offer some unique advantages. The rectal and vaginal routes belong to the transmucosal routes of drug delivery and thus offer the advantage of bypassing first-pass metabolism. They both have a use in systemic drug delivery when the oral route is not available, or where the drug under consideration is not well suited for oral administration, however these are relatively less popular due to their anogenital nature and privacy aspects.