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Several excipients in combination were required to achieve high drug solubility for a long lasting effect, the drug was prone to oxidation in excipients and some key solubilising excipients have a strong unpleasant odour.
Super Refined™ solutions for transdermal drug delivery systems
Transdermal drug delivery systems (TDDS) deliver specific doses of medication through the skin into the systemic circulation for therapeutic effects. TDDS is a non-invasive, painless method of delivering drugs, by applying a drug formulation onto intact and healthy skin and has recently emerged as an alternative to conventional needle injections. Benefits include ease of administration, convenience, and persistence amongst patients.Our Super Refined™ excipients ensure that your formulation is stable, effective, and consistent, and thanks to their high purity they also have a reduced skin irritation effect, compared to standard grade excipients.
Advantages of transdermal delivery systems
- Controlled release
- Improved drug bioavaiability
- Self-administration and reduced dosing frequency
- Minimises adverse effects and easy to terminate
- Suited for lipholic active pharmaceutical ingredient (API).
Disadvantages of transdermal delivery systems
- Possibility of local skin irritation
- Use of multiple patches can lead to medication error.
Transdermal excipient selection criteria
- Selection of patch design
- Solubility between API and excipient blend
- Physical and chemical compatibility between API and excipient blend
- Impact of excipient blend on skin permeation
- Impact of excipient blend on non-drug substance related impurities
- Impact of excipients on adherence for duration of wear period.
How our high purity excipients can help
- Excellent API solubility
- Excellent oxidation stability
- Excellent hydrolysis stability
- Low cellular irritation
- Better skin permeation enhancement
- Reduced odour impact.
Product benefits and claims
Our range of excipients are multicompendial and meet standards of international pharmacopoeias. Our products offer batch to batch consistency and our global manufacturing infrastructure, expert regulatory support and application know-how make us the partner of choice!
We help our customers formulate medicines with claims relevant to their customers, increasing the superiority of their product and brand.
We help our customers formulate medicines with claims relevant to their customers, increasing the superiority of their product and brand.
Product recommendations
13 items available
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Super Refined™ DMI
High purity liquid for use with poorly soluble hydrophilic and hydrophobic actives. Enhances the formulation and API stability in transdermal delivery systems. Recommended topical usage levels of 2-10%.
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Super Refined™ PEG 400
The Super Refined PEG range is a series of Super Refined polyethylene glycols, offering pharmaceutical formulators highly purified hydrophilic excipients that can enhance active and formulation stability....
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Super Refined™ DEGEE
Super Refined DEGEE is a multi-compendial, high purity glycol ether. This clear, colourless liquid demonstrates outstanding permeation enhancement and improved delivery and bioavailability for topical,...
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Super Refined™ IPM
Highly purified version of Crodamol IPM. Solvent used in topical formulations. Rapid absorption into the skin. Recommended topical usage levels of 0.5-5%.
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Super Refined™ PGML
Super Refined™ PGML is a high purity mixture of propylene glycol and esters of lauric (C12) acid. More specifically, as part of the Type II classification, it has at least a 90% concentration of monoesters,...
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Super Refined™ Polysorbate 80
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes impurities (including primary and secondary...
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Crodamol™ DA pharma
Diisopropyl adipate (DIPA) is a multifunctional light, non-occlusive, non-oily emollient. Its very low viscosity results in excellent spreading properties, rapid absorbency and low residual tack on the...
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Super Refined™ Oleic Acid
Highly purified oleic acid is used as a co-emulsifier in topical pharmaceutical formulations. Ideal for nasal drug delivery and as a penetration enhancer in transdermal formulations. In addition, it can...
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UltimoPure™ Isostearic Acid
Super Refined Isostearic Acid is a vegetable-derived liquid fatty acid that offers a light lubricious skin feel, preventing a dry afterfeel from topical products. It promotes low viscosity for good spreading...
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Super Refined™ Propylene Glycol
Super Refined Propylene Glycol is a highly purified propylene glycol that has a wide use in pharmaceutical formulations as a solvent, stablilising agent, water-miscible cosolvent, plasticiser, humectant,...
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Super Refined™ Oleyl Alcohol
Highly purified lipid-based solubiliser and skin penetration enhancer. Ideal for wetting and dispersing actives within topical creams and ointment applications. It is an ideal excipient for use in transdermal...
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Super Refined™ Oleyl Oleate
Highly purified version of Oleyl Oleate. A plant-derived light and non-greasy emollient.
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Super Refined™ IPP
Highly purified grade of pharmaceutical isopropyl palmitate. An easy-spreading, non-occlusive dry emollient. Required HLB value of 10. Recommended topical usage levels of 0.5-5%.
Super Refined™ PEG 400, Super Refined Castor Oil and Crodamol™ DA Pharma offer the API solubility required when combined.
Crodamol DA Pharma is low in odour compared to competitor diisopropyl adipate
Super Refined Polysorbate 80 helps compatibilise the formulation excipients
Our Super Refined excipients and Crodamol DA Pharma have superior stability, protecting the formulation from drug degradation.
Pack claims unlocked:
- Odourless
- Fast acting pain relief
- Less frequent application.