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Several excipients in combination were required to achieve high drug solubility for a long lasting effect, the drug was prone to oxidation in excipients and some key solubilising excipients have a strong unpleasant odour.
Super Refined™ solutions for transdermal drug delivery systems
Transdermal drug delivery systems (TDDS) deliver specific doses of medication through the skin into the systemic circulation for therapeutic effects. TDDS is a non-invasive, painless method of delivering drugs, by applying a drug formulation onto intact and healthy skin and has recently emerged as an alternative to conventional needle injections. Benefits include ease of administration, convenience, and persistence amongst patients.Our Super Refined™ excipients ensure that your formulation is stable, effective, and consistent, and thanks to their high purity they also have a reduced skin irritation effect, compared to standard grade excipients.
Advantages of transdermal delivery systems
- Controlled release
- Improved drug bioavaiability
- Self-administration and reduced dosing frequency
- Minimises adverse effects and easy to terminate
- Suited for lipholic active pharmaceutical ingredient (API).
Disadvantages of transdermal delivery systems
- Possibility of local skin irritation
- Use of multiple patches can lead to medication error.
Transdermal excipient selection criteria
- Selection of patch design
- Solubility between API and excipient blend
- Physical and chemical compatibility between API and excipient blend
- Impact of excipient blend on skin permeation
- Impact of excipient blend on non-drug substance related impurities
- Impact of excipients on adherence for duration of wear period.
How our high purity excipients can help
- Excellent API solubility
- Excellent oxidation stability
- Excellent hydrolysis stability
- Low cellular irritation
- Better skin permeation enhancement
- Reduced odour impact.
Product benefits and claims
Our range of excipients are multicompendial and meet standards of international pharmacopoeias. Our products offer batch to batch consistency and our global manufacturing infrastructure, expert regulatory support and application know-how make us the partner of choice!
We help our customers formulate medicines with claims relevant to their customers, increasing the superiority of their product and brand.
We help our customers formulate medicines with claims relevant to their customers, increasing the superiority of their product and brand.
Product recommendations
12 artículos disponibles
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Super Refined™ DMI
Super Refined™ DMI se destaca por ser un solubilizante altamente purificado, además de funcionar como potenciador de la permeación epidérmica y agente esparcidor. Sus aplicaciones incluyen la administración...
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Super Refined™ PEG 400
Los PEGs Super Refined son solventes para usar con ingredientes activos sensibles a través de diversas formas de dosificación incluyendo inyectables y orales. El Super Refining elimina las impurezas...
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Super Refined™ DEGEE
Super Refined™ DEGEE es ideal para su uso en aplicaciones tópicas y transdérmicas, siendo especialmente eficaz para potenciar la permeación de ingredientes farmacéuticos poco solubles en agua a través...
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Super Refined™ IPM
El Grado altamente purificado de miristato de isopropilo se emplea con ingredientes farmacéuticos activos sensibles o en aplicaciones en las que el IPM estándar de Crodamol no es adecuado.El proceso patentado...
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Super Refined™ Polysorbate 80
Los polisorbatos Super Refined se emplean para solubilizar y estabilizar los ingredientes activos más sensibles a través de diversas formas de dosificación, incluyendo inyectables y orales. El Super...
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Crodamol™ DA pharma
Ester de viscosidad muy baja, soluble en alcohol y sistemas alcohólicos acuosos. Excelentes propiedades de solvencia y dispersión. Valor HLB requerido de 9. Niveles de uso tópico recomendados de 0,5-5%.
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Super Refined™ Oleic Acid
Acido Oleico Super Refined es un ácido oleico altamente purificado, adecuado para su uso en aplicaciones de dosis tópica, oral y nasal, que actúa como un agente solubilizante, emulsionante y potenciador...
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UltimoPure™ Isostearic Acid
El Prisorine 3505 es un ácido graso líquido derivado de vegetales que ofrece una ligera sensación de piel lubricada, evitando la sensacion de resequedad de los productos tópicos. Genera baja viscosidad...
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Super Refined™ Propylene Glycol
El Propilenglicol Super Refinado es un propilenglicol altamente purificado que puede ser aplicado como disolvente, agente estabilizante, codisolvente miscible en agua, plastificante, humectante, desinfectante...
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Super Refined™ Oleyl Alcohol
El Novol NF Super Refined es un solubilizador altamente purificado basado en lípidos y potenciador de la penetración de la piel que actúa como agente humectante y dispersante de activos en cremas tópicas...
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Super Refined™ Oleyl Oleate
Versión de alta pureza del oleato de oleíla. Un emoliente vegetal ligero y no grasoso.
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Super Refined™ IPP
Grado farmacéutico de palmitato de isopropilo que ha sido altamente purificado. Emoliente seco y no oclusivo. Valor de HLB requerido de 10. Niveles de uso tópico recomendado de 0,5-5%.
Super Refined™ PEG 400, Super Refined Castor Oil and Crodamol™ DA Pharma offer the API solubility required when combined.
Crodamol DA Pharma is low in odour compared to competitor diisopropyl adipate
Super Refined Polysorbate 80 helps compatibilise the formulation excipients
Our Super Refined excipients and Crodamol DA Pharma have superior stability, protecting the formulation from drug degradation.
Crodamol DA Pharma is low in odour compared to competitor diisopropyl adipate
Super Refined Polysorbate 80 helps compatibilise the formulation excipients
Our Super Refined excipients and Crodamol DA Pharma have superior stability, protecting the formulation from drug degradation.
Pack claims unlocked:
- Odourless
- Fast acting pain relief
- Less frequent application.